●The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1 Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSmediated activation of PI3K/Akt/NFκB signaling pathways8 Chapter 3Natural products for cancer prevention associated with Nrf2ARE pathway23 Chapter 4Antitumor effect31 4.1Potential molecular targets of ampelopsin in prevention and treatment of cancers31 4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39 4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways：involvement of p38 and ERK48 Chapter 5Neuroprotective effect59 5.1Ampelopsin inhibits H2O2induced apoptosis by ERK and Akt signaling pathways and upregulation of heme oxygenase159 5.2Ampelopsin attenuates 6OHDAinduced neurotoxicity by regulating GSK3β/NRF2/ARE signaling67 Chapter 6Autophagy and brain aging77 6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77 6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80 6.3Ampelopsin attenuates brain aging of Dgalinduced rats through miR34amediated SIRT1/mTOR signaling pathway89 6.4Swimming attenuates Dgalactoseinduced brain aging via suppressing miR34amediated autophagy impairment and abnormal mitochondrial dynamics101 6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130amediated autophagy112 Chapter 7Sarcopenia123 7.1Research progress of sarcopenia123 7.2MicroRNAregulated proinflammatory cytokines in sarcopenia127 7.3Ampelopsin attenuates Dgalinduced oxidative stressrelated skeletal muscle atrophy through activating AMPK/SIRT1/PGC1α signaling cascade135 7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147 Acknowledgement155 References156
內容簡介
蛇葡萄素（Ampelopsin）又名雙氫楊梅素（dihydromyricetin，DMY）是籐茶中一種重要的黃酮類物質。研究表明，Ampelopsin具有廣泛的生物學功能：抗炎、抗氧化、抗腫瘤、保肝、改善運動疲勞等。本書首從Ampelopsin的結構入手，然後分章節來探討Ampelopsin的抗炎、抗氧化、抗腫瘤、保肝、神經保護、改善運動疲勞及衰老性肌萎縮的作用；闡明Ampelopsin發揮上述作用的信號分子或者靶標；Ampelopsin發展成為功能性食品的前景。
Ampelopsis grossedentata is widely distributed in the South of China.Its tender stems and leaves are exploited in China to prepare a health beverage named as Rattan tea.Ampelopsin is one of the most important flavonoids found in Rattan tea.As a dihydromyricetin (DHM)，ampelopsin was first isolated from Ampelopsis meliaefolia by Kotake and Kubota in 1940，and was reported as a......
Ampelopsis grossedentata is widely distributed in the South of China.Its tender stems and leaves are exploited in China to prepare a health beverage named as Rattan tea.Ampelopsin is one of the most important flavonoids found in Rattan tea.As a dihydromyricetin (DHM)，ampelopsin was first isolated from Ampelopsis meliaefolia by Kotake and Kubota in 1940，and was reported as a major bioactive compone......
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