1 ORGANIZATION OFTHE NERVOUS SYSTEM
Introduction
Overview of brain anatomy
Internal anatomy of the brain
Ventricular system
Forebrain
Hemisphere specialization
Limbic system
Orbitofrontal cortex
Basal ganglia
Diencephalon
Thalamus
Hypothalamus
Peripheral nervous system
Putting it all together: from anatomy to behaviour
2 ELEMENTS OF CELLULAR AND MOLECULAR NEUROSCIENCE
Introduction
Neurones
Glial cells
Neurone excitability
Neurotra mitte
Postsynaptic events and postsynaptic recepto
3 CLINICAL EXAMINATION
Introduction
Parts of the clinical examination
Other investigatio
General comments
4 THE SPINAL CORD
Introduction
Gross anatomy of the spinal cord and vertebral
column
Functional organization of the spinal cord
Spinal cord cell types
Receptive fields
Somatose ory pathways
Blood supply to the spinal cord
Damage to the spinal cord
Comments on the case history
5 PAIN AND ANALGESIA
Introduction
Nocicepto
Pain pathways
How does the central nervous system interpret a
stimulus as painful?
Physiology of pain modulation
Pain mechanisms after tissue damage: peripheral and
central se itization
Neuropathic pain mechanisms
Pharmacology of pain
Other approaches to pain management
General comments on pain management
6 CRANIAL NERVES AND THE BRAINSTEM
Introduction
Anatomical organization of cranial nerves in the brain
Internal organization of the brai tem
Reticular formation
Blood supply to the brai tem ~
Brai tem reflexes
Brai tem lesio
Comments on the case history
7 THE VISUAL SYSTEM
Introduction
Structure of the eye
Visual pathways
Visual field defects
Pupillary light reflexes
Focusing of light on the retina
Control of eye movements
Structure and function of the retina
Processing of visual information
Summary
8 HEARING AND BALANCE: THE AUDITORY AND VESTIBULAR SYSTEMS
Introduction
The auditory system
The vestibular system
Comments on the case history
9 MOTOR SYSTEMS h DESCENDING PATHWAYS AND CEREBELLUM
Introduction
Skeletal muscle contraction
Reflexes
Descending pathways
Clinical importance of reflexes
The cerebellum
10 MOTOR SYSTEMS II: THE BASAL GANGLIA
Introduction
The basal ganglia: structure and organization
Parki on's disease
Huntington's disease
11 STROKE AND HEAD iNJURY
Introduction
Physiological control of cdrebral blood flow
Blood supply to the brain
Venous system
Functional anatomy of the cerebral vasculature
Angiography
Stroke
Head injury
Comments on the case history
12 INFECTION IN THE CENTRAL NERVOUS SYSTEM
Introduction
Types of infection of the central nervous system
The meninges
Cerebrospinal fluid production and circulation
The blood-brain barrier
Meningitis
Diagnosis and treatment of meningitis
Treatment of meningitis
Encephalitis
Cerebral abscesses
Brain infectio in the immunocompromised patient
13 EPILEPSY
Introduction
General description of epilepsy
Epidemiology of epilepsy
Types o.f epileptic syndrome
Diagnostic investigatio of epilepsy
Different types of seizure
Neurobiology of epilepsy
Pharmacological treatment of epilepsy
Other treatments for epilepsy
Treatment of status epilepticus
Social co equences of epilepsy
14 DEMENTIA
Introduction
Causes and diagnosis of dementia
Neurobiology of learning and memory
Alzheimer's disease
Treatment of Alzheimer's disease
Other types of dementia
General co ideratio in the management of
Alzheimer's disease and other types of dementia
15 SCHIZOPHRENIA
Introduction
Schizophrenia: the clinical diagnosis
Aetiology of schizophrenia
Neurobiology of schizophrenia
Treatment of schizophrenia
Comments on the management of schizophrenia and the long-term prognosis
Other psychoses and schizophrenia-like syndromes
16 DEPRESSION AND ANXIETY
Introduction
Classification o~ mood disorde
Clinical features of mood disorde
Epidemiology of depression and natural evolution of the disease
Genetics of mood disorde
Neurobiology of depression
Treatment of depression
Bipolar disorder and its treatment
General comments on mood disorde
Need for new therapeutic targets
Comments on the case history
Anxiety disorde
Treatment of anxiety disorde
I omnia
17 ADDICTION
Introduction
Addiction and drug misuse: general comments
Opiates
Cocaine and crack
Cannabis
Nicotine
Alcohol
Phencyclidine
Amphetamines
Ecstasy--or the beginning of agony?
Hallucinoge
Solvents
Neurobiology of addiction
Addiction and rehabilitation: general issues
Index
