●Chapter 1 INTRODUCTION
1．1 Nanoparticles in Drug Delivery
1．1．1 Role of nanoparticles in drug delivery
1．1．2 Composition of drug delivery nanocarriers
1．1．3 FDA-approved therapeutic nanoagents
1．2 Design Rules for Targeted Drug Delivery Nanoplatform
1．2．1 Stimuli-responsive drug release
1．2．2 Biocompatibility and biodegradability
1．2．3 Stability， size and targeting
1．3 Photothermal Therapy
1．3．1 NIR induced photothermal therapy
1．3．2 NIR absorbing materials for photothermal therapy
1．3．3 Polymer for the delivery of NIR-absorbing dye
1．3．4 Combined photothermal-chemotherapy
Chapter 2 POLYMER-COATED HOLLOW MESOPO-ROUS SILICA NANOPARTICLES FOR TRIPLE-RESPONSIVE DRUG DELIVERY
2．1 Introduction
2．2 Materials and Methods
2．2．1 Preparation of o-nitrobenzyl linkage
2．2．2 Preparation of PDEAEMA coated HMSNs
2．2．3 Preparation of DOX-loaded nanoparticles
2．2．4 Drug release behavior
2．2．5 Cellular uptake study
2．2．6 Cytotoxicity study
2．3 Results and Discussiona
2．3．1 Preparation of HMSNs-PDEAEMA
2．3．2 Loading and triggered release of DOX
2．3．3 Cellular uptake and intracellular release
2．3．4 In vitro antimmor study
2．4 Conclusion
Chapter 3 POLYMERIC PRODRUG GRAFTED HOLLOW MESOPOROUS SILICA NANOPAR-TICLES ENCAPSULATING NIR-ABSOR BING DYE FOR POTENT COMBINED PHOTOTHERMAL-CHEMOTHERAPY
3．1 Introduction
3．2 Materials and Methods
3．2．1 Synthesis of HMSNs-RAFT
3．2．2 HMSNs-DOX prodrug
3．2．3 Preparation of HMSNs-DOX/IP
3．2．4 Drug release， dye loading and photothermal effect
3．2．5 Cellular uptake study
3．2．6 In vitro cytotoxicity study
3．3 Results and Discussion
3．3．1 Synthesis and characterization of HMSNs-DOX
3．3．2 Drug release， dye loading and photothermal effects
3．3．3 Cellular uptake and intracellular release
3．3．4 In vitro antitumor study
3．4 Conclusion
Chapter 4 ACID-SENSITIVE POLYMERIC DOXORUBICIN PRODRUG MICELLES ENCAPSULATING NEAR-INFRARED DYE FOR TARGETED COMBINED PHOTOTHERMAL-CHEMOTHERAPY
4．1 Introduction
4．2 Materials and Methods
4．2．1 Synthesis of block copolymer
4．2．2 Folic acid modification and deprotection
4．2．3 Synthesis of DOX prodrug
4．2．4 Formation of IR．825-1oaded PDOX micelles
4．2．5 In vitro drug release
4．2．6 Cellular uptake study
4．2．7 In vitro cytotoxicity study
4．2．8 In vivo antitumor efficacy studies
4．3 Results and Discussion
4．3．1 Synthesis and characterization
4．3．2 Self-assembly behavior
4．3．3 Drug release and photothermal effects
4．3．4 IntraceUular uptake
4．3．5 In vitro antitumor study
4．3．6 In vivo combinational therapeutic efficacy
4．4 Conclusion
Chapter 5 CONCLUSION AND OUTLOOK
REFERENCES
LIST OF ACRONYMS
EPILOGUE
